Post by Noah on Aug 12, 2011 20:48:36 GMT -5
It has often been remarked that many Hamites, particularly in the Eastern group, are slow acetylators. That is, they break down medication and such at a much slower rate. Slow acetylators/metabolizers are found at a considerably higher frequency among Hamitic peoples (and Caucasoids in general, actually) than among any other populations in Africa, particularly Negroid peoples. It's indeed genetic.
And when Negroid populations are slow acetylators, they possess a mutation that Hamitic peoples and Caucasoids in general (as well as many Asians) lack:
"In Ethiopia and Somalia, up to 30% of the population are ultra-rapid metabolizers"
scholar.google.ca/scholar?q=%22In+Ethiopia+and+Somalia%2C+up+to+30%25+of+the+population+are+ultra-rapid+metabolizers%22&btnG=Search&hl=en&as_sdt=2000
"Studies of African populations indicate that approximately 40% of Yorubas in Nigeria, 10-18% of Pygmies and 70% of Somalis are slow acetylators."
www.futuremedicine.com/doi/abs/10.2217/17410541.4.2.123
"a study of Egyptians indicated that between 72% and 94% are slow acetylators[...] Slow acetylators break down certain medicines at a very slow rate while fast acetylators break down the same medicines much more quickly"
www9.georgetown.edu/faculty/sandefur/handsonmath/downloads/pdf/hydral-s.pdf
And when Negroid populations are slow acetylators, they possess a mutation that Hamitic peoples and Caucasoids in general (as well as many Asians) lack:
"Of the 136 Sudanese individuals, eight were heterozygous for the G181 A mutation, giving a frequency of 0.029 (Table 1). The G191 A mutation could not be detected in the 50 Somalis individuals[...] the G191 A mutation, also associated with slow acetylation, is found mainly in blacks but rarely in whites or Asians"
journals.lww.com/jpharmacogenetics/Citation/1997/10000/The_NV_acetyltransferase_G191_A_mutation_among.9.aspx
"The absence of the 191 G>A SNP in Somalis probably reflects their Hamitic origin (18). The higher incidence observed in our study is compatible with the fact that Guinea-Bissau occupies the most western location of the African countries studied so far, supporting the idea of a western African origin of the 191 G>A mutation."
dx.doi.org/10.1515%2FCCLM.2003.091